The Unanswered Question About Malignant Tumors
This article originally appeared on recnac.org.
Yes, plenty of mechanisms cause malignant tumors. Did cancer come from differentiated, somatic cells that are already mutated, or stem/progenitor cells that are already mutated? We still do not know the right answer to the question, but we will keep trying to find out. In various malignancies there have been recognized cells that express primitive phenotype, and postulated to act as cancer stem cells (CSCs).
Cancer stem cells’ connections to non-malignant stem cells remains unclear to all. Favoritism was given to recognized cells in adult tissues communities of early development cells, because those cells could be the origin of some primitive tumors. Surprisingly, the firm belief that adult tissues have early development cells with embryonic features that can lead to tumors is not completely novel.
Throughout the 19th and the 20th century, numerous scientists divulged that cancer could start in communities of cells that are left dormant in the developing organs during embryogenesis. That information did give to initial basis to the so-called embryonic-rest-hypothesis-of-cancer-origin that Recamier said in 1829. In 1854, Remak stated what Recamier stressed.
In 1855, Virchow gave a nice amount of details regarding cancer in its end form. In 1874, Durante had his chances to speak on that cancer topic. In 1875, Cohnheim let the world know what he thought about it. The putative cells in question at that time stayed elusive & they were not recognized thoroughly. Those cells also were not purified from adult tissues.
If the embryogenesis-rest-hypothesis-of-cancer-origin was true, adult tissues would have had the embryonic remnants that usually laid dormant, but they could have been revved up to become malignant. In 1910, Wright proposed a germinal cell origin of the Wilm’s tumor (nephroblastoma). In 1911, Beard stated that tumors derive from dislocated & activated trophoblasts or dislocated germline cells.
Way back then, they did not call them stem cells that often with the scientific language. It should be quite alright to think that they had faith that such cells would be filled with properties that are like cell properties as we comprehend those currently.
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