Prostate Cancer Risk Lower in Circumcised Males
Dr. Noel Pabalan from Angeles University Foundation in Angeles City, the Philippines, and colleagues reported that prostate cancer risk is lower in circumcised males. The research team explained that other studies done previously could not confirm the associations between prostate cancer and circumcision in men. The aim of their study was to obtain a more accurate statistic by conducting a meta-analysis to confirm the association.
This study involved 8,633 men from England, Canada, and the United States. Out of the 7 case-control studies, 3 studies were statistically significant while only two studies showed lower prostate cancer risk in circumcised males. In terms of percentage, there is a 12% lower prostate cancer risk in circumcised males. In a subgroup analysis of men after prostate-specific antigen test, black men and men more than 40 years old had 17% reduction in prostate cancer risk. The research team commented that the constant result seen in this subgroup analysis strongly support the association between prostate cancer and circumcision status. They further confirmed that the best reduction of prostate cancer risk is observed in men after prostate-specific antigen testing. Their statement was based on their study result showing that the reduction in prostate cancer risk is especially strong in men more than 40 years old or who are black.
However, the research team noted that a retrospective approach in all of their studies is a limitation itself. They explained that they could not find any prospective cohort study to include. Another limitation noted by them was that all of the circumcision was self-reported by the participants of this study instead of a confirmation through medical examination. Therefore, there could be some inaccurate data which may affect the results. Despite all the study limitations, the research team explained that this study is the first study that confirms the association between prostate cancer and circumcision in men. They added that a timely circumcision in males before any sexual activity is vital in lowering the risk of prostate cancer as a lower risk of sexually transmitted infection is a mediator between circumcision and lower prostate cancer risk.