MEDI-4736: A New Drug For Colorectal Carcinoma To Begin Phase II Trial

AstraZeneca has announced early Friday that the company begin a Phase II trial for the MEDI-4736 drug which is an immuno-oncology medicine for colorectal carcinoma. MEDI-4736 is designed to assist the immune system in fighting tumours.

A total of 48 patients with advanced colorectal carcinoma will be enrolled in the Phase II trial according to an update by Of all cancer-related deaths in the country, the third highest number of deaths was contributed by colorectal carcinoma. Apart from colorectal carcinoma, MEDI-4736 has been study for indication in lung cancer along with various head and neck cancer. Briggs Morrison, the Head of medicine development said earlier in July that AstraZeneca might begin tests for another indication in 2014 but did not specify colorectal carcinoma as the indication.

MEDI-4736 belongs to a class of drugs known as anti-PD-L1 therapies. Drugs from this class inhibit a tumour's ability to evade the immune system. From a business point of view, MEDI-4736 is seen as AstraZeneca's new drug hope in an attempt to convince investors to invest in the group which has a future as an independent company. In a race to develop the first drug in the immuno-oncology class, AstraZeneca is ranked No.4 behind rivals including Merck & Co.

Company analyst forecasted that the drug will help sales rise by 75 percent come 2023. This Phase II study is not yet available for recruitment and is being conducted by Memorial Sloan-Kettering Cancer Center in New York in a collaborative effort with the pharmaceutical firm AstraZeneca.

More data on MEDI-4736 in treatment of lung cancer along with various head and neck cancer will be presented by the British drugmaker at an upcoming conference in Madrid, Spain by the end of September.

In recent years, AstraZeneca has become known for Crestor, a cholesterol drug and also Nexium, an ulcer and heartburn pill.

Photo by Wikimedia Commons.


About writershibe

writershibe is a final year medical student with a flair for writing.


Top Posts | Clinical Trials

Side Effects Reduced in New Brain Cancer Treatment

A great new form of brain cancer treatment may be able to provide patients with fewer side effects than ever before. Traditional methods of radiation treatment generally involve many side effects that are difficult to cope with like hair loss, reddening of the skin, nausea, fatigue and more. This n ...

8 Cancer Clinical Trial Facts Every Patient Should Know

In the past few decades, outstanding scientific advances have been made. These breakthroughs can prove useful while treating cancer patients. But this is possible only when these new techniques are experimented in a clinical trial to find out its usefulness and accuracy. However, this is only possi ...

New Clinical Trial for Metastatic Cancer to the Spine

As technology continues to evolve, medical research can be conducted at a more efficient pace. New minimally invasive techniques have changed the way we think about surgical intervention. To start 2015 on the right foot in the combat against cancer, a team of physicians from Loyola University Medic ...

Are Clinical Trials Right For You?

‘Clinical trials’ is a term often heard mentioned when someone is diagnosed with a critical illness. But what exactly are clinical trials? What is involved? Will the treatment actually help you or could it make you worse? This article aims to explain what to expect if you are approached ... ...