Recnac

Long Term Benefits of Immunotherapy on Skin Cancer Revealed

A recent report of follow-up findings on participants in an international clinical trial which began in 2006 has shown that immunotherapy is beneficial to those with advanced melanoma.  The findings show that remissions can be long-lasting which is great news for people fighting against cancer.

Encouraging results

Following the long-term study, over 18% of those who participated were still alive after treatment with ipilimumab(Yervoy) in combination with a chemotherapy drug called dacarbazine.  Only 9% of those treated solely with chemotherapy survived. There were also very low rates of notable side effects among patients who used the drug in the long-term.

Ipilimumab is a cancer treatment that is designed to target the patient’s immune system.  It works by focusing on the molecule called CTLA-4 which is found on immune cells.  This effectively allows the immune cells to go into overdrive and try to defend the body against the invading cancer. Bristol-Myers-Squibb, the company who manufactures the drug, funded the study.

Findings

The findings of this long follow-up analysis study of the trial results were published in the Journal of Clinical Oncology in June 2011.  In December 2012, ipilimumab received approval by NICE, the National Institute of Health and Care Excellence and was then released for use by the NHS across the United Kingdom and latterly in Scotland.

Cancer immunotherapy experts welcomed the new figures.  It was known that some patients responded well to ipilimumab but it wasn’t proven that there were long term survival benefits until the follow-up study results were published.

In conclusion

There are exciting times ahead in the field of immunotherapy study.  Years of hard work are now beginning to show results and there are several new drugs under development.  The next task for experts will be working out just how to combine them, and who will benefit the most.

Image sourceCancer Research UK

 

 

Alison Page

About Alison Page

Alison is a small business owner, freelance writer, author and dressage judge. She has degrees in Equine Science and Business Studies. Read her full story at http://www.theladywriter.co.uk

Alison Page

Top Posts | Research

Mediterranean diet

Mediterranean Dietary Lifestyle May Prevent Breast Cancer

Dr. Miguel Á. Martínez-González, MD, from the Instituto de Salud Carlos III in Madrid, and colleagues reported that breast cancer may be prevented by adopting a Mediterranean diet lifestyle that is known to be protective against cardiovascular diseases. The Mediterranean diet c ... ...

Immunological Cancer Therapy Takes Precedence

The human body is very tough. It can take a lot of abuse and still manage to function. However, just like a well-built machine, it is the internals of the human body that matter more than what is outside. So if something attacks from within, there is a chance that it may be enough to take over the ...

Sitting Linked to Increased Risk for Cancer in Women

According to a study conducted by the American Cancer Society, sitting too much can raise cancer risk in females. The study shows that women who spend 6 hours or more of their time sitting have increased cancer risk by 10% in comparison to the women who spend 3 hours of their time per day sitting.T ...

Light to Moderate Alcohol Intake Increases Cancer Risk

Dr. Edward L. Giovannucci, MD, ScD, Professor of Nutrition, Harvard T. H. Chan School of Public Health, Boston, and colleagues reported that light to moderate alcohol intake increases cancer risk. The research team urged for updated health precautions on alcohol intake. The research team explained ...

Coffee Might Lower the Recurrence Risk of Colon Cancer

Dr. Charles Fuchs, MD, MPH, from the University of Dana-Farber Cancer Institute in Boston and colleagues reported that coffee might lower the recurrence risk of colon cancer. Despite their findings, the research team warned that these findings are not evidence of causation and are only associations ...