Elimination of Helicobacter Pylori Lowers Gastric Cancer Risk in Healthy Individuals

Dr. Alexander Ford, MBChB, MD, from St. James's University Hospital and Leeds University in the United Kingdom, and team have reported that elimination of Helicobacter pylori lowers gastric cancer risk in healthy individuals. This systematic review of six trials was published recently in Cochrane Database of Systematic Reviews. Dr. Alexander Ford cautioned that five positive trials were mainly based on Asian populations and this data cannot be extrapolated to other populations.

Dr. Alexander Ford and team conducted their trials on 6,497 asymptomatic, healthy adults who tested positive for the presence Helicobacter pylori. The definition of gastric cancer was established as any gastric adenocarcinoma, including the diffuse (undifferentiated) type or intestinal (differentiated) type or without specified histology type. Therapy used to eradicate Helicobacter pylori consists of a 7- to 14-day course of antibiotics either monotherapy or in combination with bismuth, acid suppressant therapy, or both. The asymptomatic, healthy adults were divided into two groups for these trials. One group was the group with antibiotic treatment and the other group was without treatment or was on placebo.

Their study result showed that the incidence of gastric cancer was 51 of 3294 people in the antibiotic treatment group as compared with 76 of 3,203 people in the placebo or no treatment group. Two cases in the treatment group developed esophageal cancer as compared with one case in the placebo or no treatment group. Further details of the study result can be found here. Dr. Alexander Ford and team admitted that they could not assess the balance between harms and benefits of population treatment and screening for Helicobacter pylori infection if these methods were adopted as a public health measure. Dr. Alexander Ford added that this systematic review emphasized the need for further trials in different populations to show more evidence that elimination of Helicobacter pylori can lower gastric cancer risk in healthy individuals and these trials should demonstrate both the harms and benefits of such an approach.

Image Source

Reference Source


About CancerWarrior

Courage, above all things, is the first quality of a warrior. To war with Cancer.


Top Posts | Research

Mediterranean diet

Mediterranean Dietary Lifestyle May Prevent Breast Cancer

Dr. Miguel Á. Martínez-González, MD, from the Instituto de Salud Carlos III in Madrid, and colleagues reported that breast cancer may be prevented by adopting a Mediterranean diet lifestyle that is known to be protective against cardiovascular diseases. The Mediterranean diet c ... ...

Immunological Cancer Therapy Takes Precedence

The human body is very tough. It can take a lot of abuse and still manage to function. However, just like a well-built machine, it is the internals of the human body that matter more than what is outside. So if something attacks from within, there is a chance that it may be enough to take over the ...

Sitting Linked to Increased Risk for Cancer in Women

According to a study conducted by the American Cancer Society, sitting too much can raise cancer risk in females. The study shows that women who spend 6 hours or more of their time sitting have increased cancer risk by 10% in comparison to the women who spend 3 hours of their time per day sitting.T ...

Light to Moderate Alcohol Intake Increases Cancer Risk

Dr. Edward L. Giovannucci, MD, ScD, Professor of Nutrition, Harvard T. H. Chan School of Public Health, Boston, and colleagues reported that light to moderate alcohol intake increases cancer risk. The research team urged for updated health precautions on alcohol intake. The research team explained ...

Coffee Might Lower the Recurrence Risk of Colon Cancer

Dr. Charles Fuchs, MD, MPH, from the University of Dana-Farber Cancer Institute in Boston and colleagues reported that coffee might lower the recurrence risk of colon cancer. Despite their findings, the research team warned that these findings are not evidence of causation and are only associations ...